A Dynamic Multiple Input Description of Lactose Operon Expression

SHAOPING, WANG and WEIJIE, WANG (2018) A Dynamic Multiple Input Description of Lactose Operon Expression. In: Sixth International Conference on Advances in Bio-Informatics, Bio-Technology and Environmental Engineering - ABBE 2018, 28-29 April, 2018, Zurich, Switzerland.

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Modeling the regulation of lactose operon expression is significant to understand lactose metabolism at the cell-level, in which the repressor and cAMP-CRP can influence its regulation process. In this paper, a mathematic model of lactose operon expression is established in differential equations with the knowledge of system biology. Considering multiple factors such as lactose, glucose, repressor, permease, β-galactosidase, allolactose and cAMP-CRP, this paper presents dynamic bi-direction regulatory mechanisms in both repressor and cAMP-CRP with the logical “AND� of system biology. The experimental data indicates that the proposed model is more approach to the real condition.

Item Type: Conference or Workshop Item (Paper)
Uncontrolled Keywords: system biology, mathematical modeling, lactose operon expression
Depositing User: Mr. John Steve
Date Deposited: 08 Mar 2019 14:55
Last Modified: 08 Mar 2019 14:55
URI: http://publications.theired.org/id/eprint/197

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