Protective action of herbal melanin against carbon tetrachloride induced Hepatotoxicity

ADIL, HASEEB and ADILA, EL-OBEID and KAMAL, EL DIN EL TAHIR and MOHAMED, ANWAR K ABDELHALIM (2015) Protective action of herbal melanin against carbon tetrachloride induced Hepatotoxicity. In: Third International Conference on Advances in Applied Science and Environmental Engineering - ASEE 2015, 11-12 APRIL 2015, Kuala Lumpur, Malaysia.

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The present study investigated the efficacy of a herbal melanin derived from Nigella sativa L. seed coats (NS melanin) on prevention of carbon tetrachloride (CCl4) induced acute hepatic injury in Wistar rats. Hepatic damage due to CCl4 intoxication was assessed by quantifying the markers of hepatic oxidative damage, aspartate transaminase (AST), alanine transaminase (ALT) and hepatic liver peroxide marker malondialdehyde (MDA). Treatment of the rats with CCl4 increased the levels of AST, ALT in the blood and MDA in liver homogenate. Pre-treatment with herbal melanin solutions resulted in significant reduction in the levels of the hepatic enzymes and peroxides in a dose related manner. Our findings provide evidence to demonstrate that Nigella sativa L. melanin has a potent hepato-protective effect on CCl4- induced liver injury in rats. It is proposed that the action of melanin is through its antioxidative and immunomodulatory activity via activation of Toll-like receptor 4 and subsequent release of IL-6. (Abstract)

Item Type: Conference or Workshop Item (Paper)
Uncontrolled Keywords: Protective action; herbal melanin; carbon tetrachloride; hepatotoxicity
Depositing User: Mr. John Steve
Date Deposited: 07 May 2019 10:13
Last Modified: 07 May 2019 10:13

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