Rheological properties of blood serum of rats after irradiation with gamma radiation dose in vitro

ALSHERI MOHAMED, AHMAD ABD-ALHADI and MOHAMED ANWAR, K ABDELHALIM and MOHAMMED, SULIMAN AL-AYED and SHERIF A. ABDELMOTTALEB, MOUSSA (2015) Rheological properties of blood serum of rats after irradiation with gamma radiation dose in vitro. In: Third International Conference on Advances in Applied Science and Environmental Engineering - ASEE 2015, 11-12 APRIL 2015, Kuala Lumpur, Malaysia.

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Abstract

The blood serum rheological properties can open the door to many investigators to find the convenient therapy for many cases of radiation exposure. The present study aimed to investigate the rheological properties of rat blood serum at wide range of shear rates after whole body irradiation with 75Gy gamma radiation dose in vitro. Thirty healthy male Wistar-Kyoto rats weighing 200 gm were used in this study. Animals were randomly divided into gamma-irradiated rat group (irradiated with 75Gy) and control rats group. The irradiation process was carried out using Co 60 source with 0.883 cG/sec dose rate. The rheological parameters measured were viscosity (cp), %torque, shear stress (dyne/cm2) and shear rate (s-1). The rat blood serum viscosity increased significantly in the gamma-irradiated rats group corresponding to each shear rate compared with the control. The relationship between viscosity and shear rate exhibited a Non-Newtonian behavior for the control and gamma-irradiated rats group. The relationship between shear stress and % torque and shear rate exhibited a linear behavior for the control and gammairradiated rats group. The rat blood serum showed a nonsignificant change in the gamma-irradiated rats' % torque and shear stress at the lower shear rates (200-1200s-1) while a nonsignificant increase was observed at the higher shear rates (1400-1875s-1) compared with the control. The increase in blood serum viscosity might be attributed to changes in nonclotting proteins, glucose, nutrients, electrolytes, hormones, antigens, antibodies and other blood serum components, which might interfere with the antioxidant defense mechanism, leading to reactive oxygen species (ROS) generation.

Item Type: Conference or Workshop Item (Paper)
Uncontrolled Keywords: Rheological properties; gamma radiation doses; blood serum; rats
Depositing User: Mr. John Steve
Date Deposited: 07 May 2019 10:13
Last Modified: 07 May 2019 10:13
URI: http://publications.theired.org/id/eprint/1997

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