Design And Fabrication Of Polymeric Thinfilm And Ultra Thin Film Sensor Chip For Biomolecules Capturing By Surface Plasmon Resonance Technique

THIDARAT, WANGKAM and TOEMSAK, SRIKHIRIN (2014) Design And Fabrication Of Polymeric Thinfilm And Ultra Thin Film Sensor Chip For Biomolecules Capturing By Surface Plasmon Resonance Technique. In: International Conference on Advances in Environmental and Bio-Technology - AEBT 2014, 04-05 January, 2014, Bangkok.

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Abstract

Development of sensor chip to be high specificity and fitted in each application is important. This work, we designed and fabricated the sensor chips to be model of biomedical chip in form of polymethyl metacrylate(PMMA) thin film and Self-assembled monolayer (SAM) thin film which were coated on gold substrate with physisorption and chemisorption method, respectively. The detection of bimolecular interaction such as protein and collagen were tested by Surface Plasmon resonance (SPR) technique. SPR is an optical technique, which is highly sensitive on the change of the optical properties of the biomolecules in nanoscale. Thesuitable condition for protein and collagen adsorption on these two thin film were studied. It was found that the different types of surfaces on various pH condition has effect on the biomolecule adsorption. The fabricated sensor chips can be used to be the model chip for bimolecular capturing and capable to develop in medical application further.

Item Type: Conference or Workshop Item (Paper)
Uncontrolled Keywords: Surface Plasmon resonance, thin film, bimolecular capturing
Depositing User: Mr. John Steve
Date Deposited: 11 May 2019 08:00
Last Modified: 11 May 2019 08:00
URI: http://publications.theired.org/id/eprint/2176

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