Quantitative Evaluation of the Sonophoresis Efficiency for Large Nanoparticles Sonophoresis efficiency for large nanoparticles

KUN LOONG, LEE , and YUFENG, ZHOU (2014) Quantitative Evaluation of the Sonophoresis Efficiency for Large Nanoparticles Sonophoresis efficiency for large nanoparticles. In: International Conference on Advances in Bio-Informatics, Bio-Technology and Environmental Engineering - ABBE 2014, 01 - 02 June,2014, Westminster, London, UK.

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Abstract

Transdermal drug delivery has a critical contribution to medical practice and some advantages over conventional oral administration and hypodermic injection. Enhancement of percutaneous absorption or penetration of a therapeutic agent by ultrasound (sonophoresis) has been applied and studied for decades. In this study, the penetration percentage through the porcine ear skin specimen was determined quantitatively by measuring the fluorescence from nanoparticles in the size of 60 nm, 220 nm, and 840 nm in the receptor chamber at different sonication parameters. It is found that the sonophoresis efficiency increased with the acoustic intensity, duty cycle, and sonication duration, but decreased with the particle size (62.65.4% for 60 nm vs. 11.91.1% for 840 nm polystyrene nanospheres after 30 min sonication at 0.5 W/cm2 and 100% duty cycle, p 0.05). Although the pore size kept almost the same in scanning electron microscopy, more flakes were observed at the entry site with the progress of sonication. In summary, sonophoresis efficiency is dependent on the ultrasound parameters and particle size and satisfactory penetration of even sub-micro objects through the pores is feasible.

Item Type: Conference or Workshop Item (Paper)
Uncontrolled Keywords: —transdermal drug delivery, sonophoresis, fluorescent nanoparticles, quantitative drug penetration, cavitation
Depositing User: Mr. John Steve
Date Deposited: 15 May 2019 12:33
Last Modified: 15 May 2019 12:33
URI: http://publications.theired.org/id/eprint/2362

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