Open Source Drug Discovery For Chikungunya

CHETANA, SHETTY and DEEPA, MOHAN and MAYURI, RANE and PADMAVATHI, P and SANDHYA, S and VIDYA, N (2014) Open Source Drug Discovery For Chikungunya. In: International Conference on Advances in Bio-Informatics, Bio-Technology and Environmental Engineering - ABBE 2014, 01 - 02 June,2014, Westminster, London, UK.

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Abstract

Chikungunya is viral disease is transmitted to human beings by mosquito bite [2]. Chikungunya can cause fever, chills, nausea, vomiting, joint pain, head ache, and swollen in the joints. A cause of Chikungunya is mainly due to the replication of Chikungunya virus in the human body [5]. The protein E1 was used in the study which is monomer with molecular weight 50KDa which is anchored in the membrane of CHIKV. The structure of E1 was retrieved from Protein Data Bank. The PDB ID for E1 was 3N41 , which is responsible for Chikungunya virus replication. CHIKV replication is resistant to inhibition by interferon once RNA replication has been established and that CHIKV actively suppress the antiviral IFN response by preventing IFN-induced gene expression there by making host to shut-off [4,2].The report have shown that the intensity of the infection has increased with every passing year with 45%–63% attack rates in world during outbreaks India is endemic to dengue fever and due to overlapping symptoms; CHIK infection is generally mistaken to be the former thereby leading to misdiagnosis. CHIKV infection is considered an important public health problem due to the morbidity and disability caused by chronic arthralgia [2] . The social and economic burden caused by CHIKV fever is tremendous. Hence, there is an urgent need for an effective vaccine or antiviral therapy against CHIKV infection. The Homology Modeling was used to predict the 3-Dimensional structure of 3N41[4]. Docking studies were carried out with various inhibitors and it was found that ligand 1IKW had a most stable interaction with 3n41. Indicate that LIGAND 1IKW is the most promising inhibitor for CHIKV.

Item Type: Conference or Workshop Item (Paper)
Uncontrolled Keywords: CHIKV, drug design, OSDD, E1 protein, Efavirenz , Rimantidine
Depositing User: Mr. John Steve
Date Deposited: 15 May 2019 12:34
Last Modified: 15 May 2019 12:34
URI: http://publications.theired.org/id/eprint/2365

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