The Exact Specification for Consumption of Blood-Pressure Regulating Drugs with a Numerical Model of Pulsatile Micropolar Fluid Flow in Elastic Vessel

H., ASKARIAN and S., GHOLAMREZAIE and S., MADDAH (2017) The Exact Specification for Consumption of Blood-Pressure Regulating Drugs with a Numerical Model of Pulsatile Micropolar Fluid Flow in Elastic Vessel. In: Seventh International Conference On Advances in Mechanical, Aeronautical and Production Techniques - MAPT 2017, 01-02 July, 2017, Kuala Lumpur, Malaysia.

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Abstract

In the present paper, the problem of pulsatile micropolar blood flow through an elastic artery has been studied. An Arbitrary Lagrangian-Eulerian (ALE) formulation of the dominate equations have been produced to model the fully-coupled Fluid-Structure Interaction (FSI). Furthermore, those derived equations have also been numerically dealt with using finite difference scheme through exploiting a mesh generation technique which leads to a uniformly spaced grid in the computational plane. The effect of variations in cardiac output and elastic modulus of artery wall on blood pressure has been determined by utilizing blood-pressure regulating drugs like Atenolol. Also a numerical model has been prepared in order to precisely define and verify the effects of various dosage of a drug on blood flow in arteries without resorting to the inefficient prevalent experiments that could have many mistakes and costs. The numerical results have shown that the artery wall stiffness has been decreased about 29 % by Atenolol dose between 0 and 0.02 mg/kg and have a blood pressure increment between 0.02 and 0.04 mg/kg.

Item Type: Conference or Workshop Item (Paper)
Uncontrolled Keywords: Pulsatile blood flow, Atenolol, micropolar fluid, arbitrary Lagrangian-Eulerian, fluid structure interaction
Depositing User: Mr. John Steve
Date Deposited: 11 Mar 2019 11:30
Last Modified: 11 Mar 2019 11:30
URI: http://publications.theired.org/id/eprint/419

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